The RAT ANTI HUMAN CD49f Antibody from MyBioSource.com is a Rat Monoclonal antibody to CD49f, Integrin alpha 6, Integrin alpha6, and ITGA6. This antibody recognizes Human antigen. The RAT ANTI HUMAN CD49f Antibody has been validated for the following applications: Flow Cytometry, Immunohistochemistry, and Immunoprecipitation.
Description
Rat anti Human CD49f antibody, clone NKI-GoH3 recognizes CD49F (VLA-6 alpha chain), a 120kD cell surface glycoprotein that can form distinct complexes with CD29 (VLA beta-chain), resulting in the VLA-6 (alpha-6 beta-1) complex, which is expressed on human platelets, or with the beta-4 integrin resulting in the alpha-6 beta-4 complex which is expressed on various human epithelial cells. Clone NKI-GoH3 reacts with platelets, megakaryocytes, T lymphocytes and common Acute Lymphoblastic Leukaemia cells (alpha-6 beta-1). In immunohistology the monoclonal antibody reacts with epithelial cells of a variety of tissues, peripheral nerves, microvascular endothelial cells, placenta cyto- and syncytotrophoblasts.VLA-6 is an important mediator of cell binding to laminin. Studies suggest that clone NKI-GoH3 specifically blocks the binding of cells to the E8 fragment of laminin (Sonnenberg et al. 1998)